YUUTO® DEFENCE – Immunity Booster
A strong immune system protects the body from bacteria, viruses and other disease-causing pathogens.
On the other hand, a weak immune system puts the body at a higher risk of developing infectious diseases.
Yuuto® DEFENCE Immunity Booster 10x mushroom complex is a comprehensive functional mushroom blend designed specifically for anyone who would benefit from immune system support.* This potent mushroom complex helps support the protective fibers around nerves in the brain for improved cognition, clarity, and memory.* Yuuto® DEFENCE Immunity Booster is a carefully formulated supplement that supports overall health and compliments a healthy and active lifestyle.
Yuuto® DEFENCE Immunity Booster complex can be used every day to help:
- Strengthen the body’s immune system;*
- Support stress and fatigue reduction;*
- Mental clarity, memory and ability to focus;*
- Provide support for daily environmental assaults;*
- Deliver enzymes to support digestion and absorption of nutrients;*
- Provide polysaccharides to increase the activity & impact of natural killer cells and macrophages.*
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FREQUENTLY ASKED QUESTIONS (FAQs)
We have compiled a list of the most frequently asked questions here, with answers by our panel of experts.
Yuuto® DEFENCE Immunity Booster complex incorporates 10 of the most powerful medicinal mushrooms varieties in the world including Cordyceps Sinensis, Reishi, Shiitake, Lions Mane, Maitake, Turkey Tail, Chaga, Royal Sun Agaricus, White Button and Black Fungus combining all their individual benefits in one unique supplement.
Cordyceps Sinensis Powder (Mycelium): Cordyceps Sinensis is a species of mushroom that has been widely used by Traditional Chinese Medicine. Recent scientific research has revealed a wide range of benefits, which are primarily due to its high polysaccharide content. Cordyceps optimises oxygen uptake and delivery to increase vitality and endurance. Awaken energy, improve cardio and ignite your inner strength.* 
Reishi Mushroom Extract (Granoderma lucidun karst) (Fruit): Reishi mushroom is a potent fungus which has been used by the Chinese for centuries for the medicinal purpose. Reishi mushroom is a superfood (antioxidants), which helps prevent cell damage caused by free radicals or oxidants. It helps support the immune system due to beta glucan (beta-1,3-D-glucan) rich polysaccharides.* 
Shiitake Mushroom Extract (Lentinus edodes) (Fruit): Used by Chinese herbalists for over 600 years to enhance the body’s defenses, shiitake mushroom contains quite a number of essential nutrients. Some of these include dietary fiber, proteins, vitamin B, iron, manganese and copper, among others. The mushrooms also contain a special compound referred to as ergosterol. It supplies the body with the right proportions of vitamin D. The mushrooms also contain another bioactive chemical, polysaccharide lentinan. It has anti-inflammatory properties which counters the inflammation attributed to various conditions. The vitamin D present in Shiitake mushrooms is responsible for improving bone strength and density. This is turn prevents premature aging. Shiitake mushrooms are also credited with improving immunity. They polysaccharides present in the mushrooms boost cell-mediated immune responses. This way, the body is kept alert in case of invasion by any disease-causing organisms.* 
Lions Mane (Hericium erinaceus) (Fruit): Lion’s mane mushroom and its extract have been shown to have a variety of health benefits. Lions Mane is an edible mushroom that has been used in Chinese and Japanese culture for centuries. Research has found that lion’s mane may protect against dementia, reduce mild symptoms of anxiety and depression and help repair nerve damage. It also has strong anti-inflammatory, antioxidant and immune-boosting abilities and been shown to lower the risk of heart disease, cancer, ulcers and diabetes in animals.* 
Maitake Mushroom Extract (Polyporus frondosus)(Fruit): Maitake mushroom has been prized in traditional Japanese herbology for hundreds of years. Modern science has identified in maitake proteoglucan, beta-1,3 glucan and beta 1,6 glucans combined with protein, as an active constituent to support the immune system. It contains a unique protein-bound. Beta-1, 3/1, 6 glucan, D-fraction, which has been tested and found to be the strongest among many of the most powerful immune boosters. D-fraction may increase numbers of immune cells, and improve overall functioning on the immune system.*
Turkey Tail Extract (Coriolus versicolo) (Fruit): Strengthen your body’s defenses at the most fundamental level with the protective power of Turkey Tail Mushroom. Traditional Chinese and Japanese herbalists have treasured Turkey Tail Mushroom as a powerful tonic for the immune system and healthy liver function. Modern science has revealed that Turkey Tail Mushroom features polysaccharide compounds that support the body’s cellular level defenses.*
Chaga Mushroom Extract (Inonqqus obliquus) (Fruit): Chaga mushroom contains a range of important active constituents including polysaccharides, phenolic compounds, lanostane triterpenoids and melanin, a pigment that is present and needed throughout the human body, with a wide range of health benefits. Chaga contains high levels of antioxidants which help to fight free-radicals that are responsible for cell damage. A powerful adaptogen that helps the body manage stress. Chaga detoxifies the body, supports the immune system, healthy blood sugar levels and is a great supplement to take during times of stress.*
Royal Sun Agaricus Extract (Agaricus blazei) (Fruit): Originating from the mountain region of Brazil being called “Cogmelo de Deus (Mushroom of God)”, this mushroom was treasured for its health benefits and miracles. Among Japan’s most extensively researched immune-boosting mushrooms, Agaricus Blazei contains much higher concentrations of beta glucans than other tonic mushrooms such as maitake, shiitake and reishi, making it one of the world’s most powerful cellular protectors. *
White Button Mushroom Extract (Agaricus bisporus) (Fruit): White Button mushroom contain B vitamins as well as a powerful antioxidant called selenium, which helps to support the immune system and prevent damage to cells and tissues. In particular, white button mushrooms are one of the few non-animal sources of vitamin D.*
Black Fungus Extract (Auricularia auricula) (Fruit): Research indicates that black fungus offers many benefits, such as protecting your liver, lowering cholesterol, and boosting gut health. It’s also packed with fiber and antioxidants. Black fungus offers powerful antioxidants and gut-healthy prebiotics.*
- Serving Size2 Veggie Capsules
- Servings Per Container30
- Calories from Fat0
- Food ComponentAmount/Serving% Daily Value*
- Cordyceps Sinensis Powder (Mycelium)266 mg
- Reishi Mushroom Extract266 mg
- (Granoderma lucidun karst)(Fruit)
- Shiitake Mushroom Extract266 mg
- (Lentinus edodes)(Fruit)
- Lions Mane266 mg
- (Hericium erinaceus)(Fruit)
- Mushroom Proprietary Blend266 mg
- Maitake Mushroom Extract (Polyporus frondosus)(Fruit), Turkey Tail Extract (Coriolus versicolo)(Fruit), Chaga Mushroom Extract (Inonqqus obliquus)(Fruit), Royal Sun Agaricus Extract (Agaricus blazei)(Fruit), White Button Mushroom Extract (Agaricus bisporus)(Fruit), Black Fungus Extract (Auricularia auricula)(Fruit)
Inactive Ingredients: Cellulose (Vegetable Capsule), Microcrystalline Cellulose, Magnesium Stearate.
- 100% All Natural
- Suitable for Vegans: Yes
- Suitable for Vegetarians: Yes
- Third Party Tested: Yes
- 60 Veggie Capsules: 1 Month Supply
- Non-GMO / Dairy Free / Gluten Free : Yes/Yes/Yes
- USA Medicinal Mushrooms Grown
- USA manufactured in a GMP facility
- Yuuto™ Nutrition proudly uses only the highest quality ingredients
CAUTION: Do not exceed recommended dose. Pregnant or nursing mothers, children under the age of 18, and individuals with a known medical condition should consult a physician before using this or any dietary supplement.
The Supplement Facts labeling information contained within this website should be regarded as the most up to date and may differ from product labeling that you have purchased. Please consult your product package for information, including allergens, specific to the product you have purchased.
- Anyone who would benefit from immune system support;
As a dietary supplement take two (2) vegetable capsules once a day. For best results take 20-30 min before a meal with
an 8oz. glass of water or as directed by your healthcare professional. You may want to set a reminder on your phone or computer to make sure you take your supplements at correct time.
Most people begin to notice results within 5-10 days. However those results will continue to get stronger the longer you take it. We suggest at least 60-days, this will give your body enough time to cycle all the nutrients through your system several times, allowing your cells to start repairing themselves. A regular intake is recommended and should be used in conjunction with a balanced and healthy diet. There is no maximum length of time over which Yuuto® DEFENCE may be used. If you are unsure about taking supplements consult a doctor or pharmacist before use.
The information presented here is intended for informational purposes only, and is meant to help users better understand health concerns. Information is based on review of scientific research data, historical practice patterns, and clinical experience.
Food supplements must not be used as a substitute for a varied, nutritional and balanced diet. If you are pregnant, breastfeeding, taking any medication or are currently undergoing medical advice, please consult a doctor or healthcare professional before use.
Refrain from taking the food supplements if adverse reactions occur and consult a doctor.
Keep out of reach of young children.
Do not use if the goods are received without a tamper strip securely in place.
The research and studies behind Yuuto® DEFENCE – Immunity Booster complex:
 Xu YF. Effect of Polysaccharide from Cordyceps militaris (Ascomycetes) on Physical Fatigue Induced by Forced Swimming. Int J Med Mushrooms. 2016;18(12):1083-1092. doi: 10.1615/IntJMedMushrooms.v18.i12.30.
 Med Sci Sports Exerc. 2007 Jan;39(1):103-7. Maximal oxygen uptake as a parametric measure of cardiorespiratory capacity. Hawkins MN1, Raven PB, Snell PG, Stray-Gundersen J, Levine BD.
 Steve Chen, M.D., Zhaoping Li, M.D., Ph.D., Robert Krochmal, M.D., Marlon Abrazado, B.S., Woosong Kim, B.S., and Christopher B. Cooper. Effect of Cs-4® (Cordyceps sinensis) on Exercise Performance in Healthy Older Subjects: A Double-Blind, Placebo-Controlled Trial. J Altern Complement Med. 2010 May; 16(5): 585–590.
 Katie R. Hirsch, Abbie E. Smith-Ryan, Erica J. Roelofs, Eric T. Trexler, and Meredith G. Mock. Cordyceps militaris improves tolerance to high intensity exercise after acute and chronic supplementation. Published online 2016 Jul 13. doi: 10.1080/19390211.2016.1203386
 Int J Sport Nutr Exerc Metab. 2004 Apr;14(2):236-42. Cordyceps Sinensis (CordyMax Cs-4) supplementation does not improve endurance exercise performance. Parcell AC, Smith JM, Schulthies SS, Myrer JW, Fellingham G.
 Xiao Yi, Huang Xi-zhen & Zhu Jia-shi. Randomized double-blind placebo-controlled clinical trial and assessment of fermentation product of Cordyceps sinensis (Cs-4) in enhancing aerobic capacity and respiratory function of the healthy elderly volunteers. Chinese Journal of Integrative Medicine volume 10, pages187–192(2004).
 Altern Ther Health Med. 2016 Jun;22 Suppl 2:24-31. Cordyceps sinensis: Genotoxic Potential in Human Peripheral Blood Cells and Antigenotoxic Properties Against Hydrogen Peroxide by Comet Assay. Vasiljevic JD, Zivkovic LP, Cabarkapa AM, Bajic VP, Djelic NJ, Spremo-Potparevic BM.
 Phytother Res. 2009 Jan;23(1):116-22. doi: 10.1002/ptr.2576. Antiaging effect of Cordyceps sinensis extract. Ji DB, Ye J, Li CL, Wang YH, Zhao J, Cai SQ.
 Am J Chin Med. 2010;38(6):1093-106. Protective effects on mitochondria and anti-aging activity of polysaccharides from cultivated fruiting bodies of Cordyceps militaris. Li XT, Li HC, Li CB, Dou DQ, Gao MB.
 Evid Based Complement Alternat Med. 2012;2012:273435. doi: 10.1155/2012/273435. Epub 2012 Mar 29. Polysaccharides from the Medicinal Mushroom Cordyceps taii Show Antioxidant and Immunoenhancing Activities in a D-Galactose-Induced Aging Mouse Model. Xiao JH, Xiao DM, Chen DX, Xiao Y, Liang ZQ, Zhong JJ.
 Pharmacogn Rev. 2010 Jul-Dec; 4(8): 118–126. doi: 10.4103/0973-7847.70902. Free radicals, antioxidants and functional foods: Impact on human health. V. Lobo, A. Patil, A. Phatak, and N. Chandra
 Diabetes Metab Res Rev. 2015 Feb;31(2):113-26. doi: 10.1002/dmrr.2558. Role of free radical in atherosclerosis, diabetes and dyslipidaemia: larger-than-life. Singh R1, Devi S, Gollen R.
 Redox Biol. 2018 Jun;16:248-254. doi: 10.1016/j.redox.2018.02.024. Epub 2018 Mar 6. Lipid peroxidation regulates podocyte migration and cytoskeletal structure through redox sensitive RhoA signaling. Kruger C1, Burke SJ2, Collier JJ3, Nguyen TT1, Salbaum JM4, Stadler K5.
 Int J Mol Med. 2015 Oct; 36(4): 939–946. Cordyceps sinensis oral liquid prolongs the lifespan of the fruit fly, Drosophila melanogaster, by inhibiting oxidative stress. YINGXIN ZOU, YUXIANG LIU, MINGHUA RUAN, XU FENG, JIACHUN WANG, ZHIYONG CHU, and ZESHENG ZHANG.
 Am J Chin Med. 1996;24(2):111-25. Cordyceps sinensis as an immunomodulatory agent. Kuo YC1, Tsai WJ, Shiao MS, Chen CF, Lin CY.
 Toxicol Appl Pharmacol. 2003 Jul 1;190(1):1-8.
Methanol extract of Cordyceps pruinosa inhibits in vitro and in vivo inflammatory mediators by suppressing NF-kappaB activation. Kim KM1, Kwon YG, Chung HT, Yun YG, Pae HO, Han JA, Ha KS, Kim TW, Kim YM.
 J Ethnopharmacol. 2002 Nov;83(1-2):79-85. Immunomodulatory functions of extracts from the Chinese medicinal fungus Cordyceps cicadae. Weng SC1, Chou CJ, Lin LC, Tsai WJ, Kuo YC.
 Orient Pharm Exp Med. 2015; 15(1): 7–12. Anti-inflammatory effects of Cordyceps mycelium (Paecilomyces hepiali, CBG-CS-2) in Raw264.7 murine macrophages. Seong-Yeol Park, Su-Jin Jung, Ki-Chan Ha, Hong-Sig Sin, Seung-Hwan Jang, Han-Jung Chae, and Soo-Wan Chae.
 Published online 2014 Dec 5. doi: 10.1007/s13596-014-0173-3. Anti-inflammatory effects of Cordyceps mycelium (Paecilomyces hepiali, CBG-CS-2) in Raw264.7 murine macrophages. Seong-Yeol Park, Su-Jin Jung, Ki-Chan Ha, Hong-Sig Sin, Seung-Hwan Jang, Han-Jung Chae, and Soo-Wan Chae.
 Pediatr Neonatol. 2008 Oct;49(5):171-8. doi: 10.1016/S1875-9572(09)60004-8. Effects of the immunomodulatory agent Cordyceps militaris on airway inflammation in a mouse asthma model. Hsu CH1, Sun HL, Sheu JN, Ku MS, Hu CM, Chan Y, Lue KH.
 J Ethnopharmacol. 2005 Jan 15;96(3):555-61. Epub 2004 Dec 10. Anti-inflammatory and related pharmacological activities of cultured mycelia and fruiting bodies of Cordyceps militaris. Won SY1, Park EH.
 Herbal Medicine: Biomolecular and Clinical Aspects. 2nd edition. Chapter 5 – Cordyceps as an Herbal Drug. Bao-qin Lin and Shao-ping Li.
 Int Immunopharmacol. 2009 Oct;9(11):1272-80. doi: 10.1016/j.intimp.2009.07.011. Epub 2009 Aug 3. Suppression of the inflammatory response by triterpenes isolated from the mushroom Ganoderma lucidum. Dudhgaonkar S, Thyagarajan A, Sliva D.
 Published online 2013 Feb 28. doi: 10.1371/journal.pone.0057431. Anti-Tumor Effects of Ganoderma lucidum (Reishi) in Inflammatory Breast Cancer in In Vivo and In Vitro Models. Ivette J. Suarez-Arroyo, Raysa Rosario-Acevedo, Alexandra Aguilar-Perez, Pedro L. Clemente, Luis A. Cubano, Juan Serrano, Robert J. Schneider, and Michelle M. Martínez-Montemayor.
 J Dermatolog Treat. 2015 Oct;26(5):465-70. doi: 10.3109/09546634.2015.1021663. Epub 2015 Apr 20. Triterpenes with healing activity: A systematic review. Agra LC, Ferro JN, Barbosa FT, Barreto E.
 Herbal Medicine: Biomolecular and Clinical Aspects. 2nd edition. Chapter 9 – Ganoderma lucidum (Lingzhi or Reishi) A Medicinal Mushroom. Sissi Wachtel-Galor, John Yuen, John A. Buswell, and Iris F. F. Benzie.
 Int J Med Mushrooms. 2013;15(2):127-43. Probing Lingzhi or Reishi medicinal mushroom Ganoderma lucidum (higher Basidiomycetes): a bitter mushroom with amazing health benefits. Batra P, Sharma AK, Khajuria R.
 J Pharmacol Sci. 2005 Oct;99(2):144-53. Cellular and molecular mechanisms of immuno-modulation by Ganoderma lucidum. Lin ZB.
 Nutr Cancer. 2010;62(5):648-58. doi: 10.1080/01635581003605516. The effects of two different ganoderma species (Lingzhi) on gene expression in human monocytic THP-1 cells. Cheng CH1, Leung AY, Chen CF.
 Immunol Invest. 2003 Aug;32(3):201-15. Effects of ganopoly (a Ganoderma lucidum polysaccharide extract) on the immune functions in advanced-stage cancer patients. Gao Y, Zhou S, Jiang W, Huang M, Dai X.
 Hematol Oncol Stem Cell Ther. 2015 Jun;8(2):47-55. doi: 10.1016/j.hemonc.2014.11.006. Epub 2014 Dec 27. Natural killer cells: In health and disease. Mandal A, Viswanathan C.
 Int Immunopharmacol. 2006 Mar;6(3):499-508. Epub 2005 Sep 15. Monitoring of immune responses to a herbal immuno-modulator in patients with advanced colorectal cancer. Chen X, Hu ZP, Yang XX, Huang M, Gao Y, Tang W, Chan SY, Dai X, Ye J, Ho PC, Duan W, Yang HY, Zhu YZ, Zhou SF.
 Br J Sports Med. 2008 Oct;42(10):819-22. Epub 2007 Nov 29. Effect of Ganoderma lucidum capsules on T lymphocyte subsets in football players on “living high-training low”. Zhang Y1, Lin Z, Hu Y, Wang F.
 Br J Nutr. 2004 Feb;91(2):263-9. Ganoderma lucidum (“Lingzhi”), a Chinese medicinal mushroom: biomarker responses in a controlled human supplementation study. Wachtel-Galor S1, Tomlinson B, Benzie IF.
 J Am Coll Nutr. 2015;34(6):478-87. doi: 10.1080/07315724.2014.950391. Epub 2015 Apr 11. Consuming Lentinula edodes (Shiitake) Mushrooms Daily Improves Human Immunity: A Randomized Dietary Intervention in Healthy Young Adults. Dai X, Stanilka JM, Rowe CA, Esteves EA, Nieves C Jr, Spaiser SJ, Christman MC, Langkamp-Henken B, Percival SS.
 Food Funct. 2015 Aug;6(8):2653-63. doi: 10.1039/c5fo00689a. Epub 2015 Jul 2. Lentinula edodes-derived polysaccharide rejuvenates mice in terms of immune responses and gut microbiota. Xu X, Yang J, Ning Z, Zhang X.
 A Review on General Nutritional Compounds and Pharmacological Properties of the Lentinula edodes Mushroom. Food and Nutrition Sciences, 2014, 5, 1095-1105. Published Online June 2014 in SciRes.
 Food Funct. 2015 Jun;6(6):2068-80. doi: 10.1039/c4fo01192a. Lentinula edodes-derived polysaccharide enhances systemic and mucosal immunity by spatial modulation of intestinal gene expression in mice. Xu X, Yang J, Luo Z, Zhang X.
 Food Funct. 2015 Oct;6(10):3205-17. doi: 10.1039/c5fo00678c. The structure of mushroom polysaccharides and their beneficial role in health. Huang X, Nie S.
 Anticancer Agents Med Chem. 2012 Dec;12(10):1255-63. The cancer preventive effects of edible mushrooms. Xu T, Beelman RB, Lambert JD.
 Food Funct. 2017 Mar 22;8(3):1020-1027. doi: 10.1039/c7fo00071e. Immunomodulatory effects of Hericium erinaceus derived polysaccharides are mediated by intestinal immunology. Sheng X, Yan J, Meng Y, Kang Y, Han Z, Tai G, Zhou Y, Cheng H.
 Front Immunol. 2017 Jun 12;8:666. doi: 10.3389/fimmu.2017.00666. eCollection 2017. Immunomodulatory Activities of a Fungal Protein Extracted from Hericium erinaceus through Regulating the Gut Microbiota. Diling C, Chaoqun Z, Jian Y, Jian L, Jiyan S, Yizhen X, Guoxiao L
 J Agric Food Chem. 2012 Jun 6;60(22):5590-6. doi: 10.1021/jf300897w. Epub 2012 May 24. Hericium erinaceus mushroom extracts protect infected mice against Salmonella Typhimurium-Induced liver damage and mortality by stimulation of innate immune cells. Kim SP, Moon E, Nam SH, Friedman M.
 EMBO Rep. 2012 Nov; 13(11): 968–970. The inflammation theory of disease. The growing realization that chronic inflammation is crucial in many diseases opens new avenues for treatment. Philip Hunter
 Mol Med Rep. 2015 May;11(5):3794-9. doi: 10.3892/mmr.2014.3121. Epub 2014 Dec 19. Composition and antioxidant activity of water-soluble oligosaccharides from Hericium erinaceus. Hou Y, Ding X, Hou W.
 Evid Based Complement Alternat Med, 2012, 464238. Evaluation of Selected Culinary-Medicinal Mushrooms for Antioxidant and ACE Inhibitory Activities. Noorlidah Abdullah, Siti Marjiana Ismail, Norhaniza Aminudin, Adawiyah Suriza Shuib, Beng Fye Lau.
 Int J Mol Sci. 2014 Sep; 15(9): 15073–15089. Protective Effects of Hericium erinaceus Mycelium and Its Isolated Erinacine A against Ischemia-Injury-Induced Neuronal Cell Death via the Inhibition of iNOS/p38 MAPK and Nitrotyrosine. Kam-Fai Lee, Jiann-Hwa Chen, Chih-Chuan Teng, Chien-Heng Shen, Meng-Chiao Hsieh, Chien-Chang Lu, Ko-Chao Lee, Li-Ya Lee, Wan-Ping Chen, Chin-Chu Chen, Wen-Shih Huang, and Hsing-Chun Kuo.
 Int J Med Mushrooms. 2016;18(3):227-34. doi: 10.1615/IntJMedMushrooms.v18.i3.50. Anti-Inflammatory Effects of Ethanol Extract of Lion’s Mane Medicinal Mushroom, Hericium erinaceus (Agaricomycetes), in Mice with Ulcerative Colitis. Qin M, Geng Y, Lu Z, Xu H, Shi JS, Xu X, Xu ZH.
 Int J Biol Macromol. 2013 Jan;52:66-71. doi: 10.1016/j.ijbiomac.2012.09.009. Epub 2012 Sep 19. Evaluation of in vivo antioxidant activity of Hericium erinaceus polysaccharides. Han ZH, Ye JM, Wang GF.
 Int J Med Mushrooms. 2015;17(7):609-18. The Anti-Inflammatory Effects of Lion’s Mane Culinary-Medicinal Mushroom, Hericium erinaceus (Higher Basidiomycetes) in a Coculture System of 3T3-L1 Adipocytes and RAW264 Macrophages. Mori K, Ouchi K, Hirasawa N.
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